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Disadvantages, compared to sitagliptin, include an injectable dosage form and gastrointestinal side effects

Comparative Effectiveness of Dapagliflozin vs DPP-4 Inhibitors on a Composite Endpoint of HbA1c, Body Weight and Blood Pressure Reduction in the Real World

The first goal of these trials was to prove GLP-1 receptor agonists cardiovascular safety, and majority of CVOTs were designed as non-inferiority trials