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Spiller, Phillip C
CagriSema and tirzepatide achieve remarkably similar weight loss (20.4% vs 20.9%) through fundamentally different dual mechanisms -- amylin/GLP-1 versus GIP/GLP-1
As of mid-2025, retatrutide has not been approved by the MHRA and is not legally available outside regulated clinical trials in the UK
In May 2024, Roches dual GLP-1/GIP receptor agonist CT-388 produced positive findings treating obesity and type 2 diabetes in a Phase Ib clinical trial
Generally, clinical trials have shown that patients typically lose 1-2 pounds per week when combined with diet and exercise
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