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The reality across all these products is that the skin barrier effectively blocks peptides larger than 500 Daltons from absorption, making their weight loss claims scientifically implausible

For example, while semaglutide reduced the risk of clinically important kidney outcomes and death from cardiovascular causes in patients with T2D and chronic kidney disease [30], it is not known which mechanism(s) or processes from GLP-1/GLP-1R action delay the course of diabetic kidney disease, making these findings hypothesis-generating [31]

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The medication carries a significant risk of birth defects, particularly cleft lip and cleft palate

The temporal relationship between tirzepatide initiation and symptom onset, followed by normalization of thyroid function after tirzepatide discontinuation, raises the possibility of a drug-related effect