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Inflammopharmacology 29 , 11691185 (2021)

Nausea and vomiting: Food that stays in the stomach can cause feelings of fullness, bloating, and nausea, leading to vomiting in some cases

This level of spatiotemporal control achieved by the compartmentalization of signaling through internalization may be vital to specific, fine-tuned responses from GLP-1R activation and may have substantial implications both physiologically and therapeutically for targeting this receptor in disease management