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-cell apoptosis is mediated by a series of cascade mechanisms of the cysteine protease family, and current studies on hyperglycemia-induced -cell apoptosis have focused on the balance between the pro-apoptotic Bcl-2 proteins (Bad, Bid, Bik, and Bax) and the anti-apoptotic Bcl family (Bcl-2 and Bcl-xl) (Tomita, 2016), and apoptosis occurs only when the concentration of the pro-apoptotic protein Bcl-2 on the mitochondrial membrane of the intrinsic pathway exceeds the concentration of the anti-apoptotic protein

But averages obscure the distribution

18 Similarly, the claim-based frailty index was estimated from the administrative dataset using a previously validated methodology that incorporates Current Procedural Terminology (CPT) codes, Healthcare Common Procedure Coding System (HCPCS) codes, and ICD codes

On the contrary, for individuals with comorbid HF or without atherosclerotic CVD, combination therapy may be considered for improving metabolic outcomes given the scarcity of evidence and that any absolute benefits on cardiorenal outcomes are expected to be attenuated