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, Salvucci, J

These results represent a clinically relevant discovery, pointing to diminishing efficacy of exenatide in patients who develop high titers of emergent-treatment antibodies
Allow complete dissolution naturally
Obesity is linked to some of the most serious diseases in the developed world

This actually makes the 505(b)(2) value-added path more attractive as it relies on clinical differentiation rather than just price

Mark Pimentel, MD, Executive Director of the Medically Associated Science and Technology Program at Cedars-Sinai, and a leading expert on microbial overgrowths, puts it this way: Any factor that slows down the speed of flow [of food] through the small intestine has the potential to cause [bacterial] overgrowth. This is important for patients assessing their SIBO risk, because studies suggest GLP-1 signaling can inhibit aspects of the Migrating Motor Complex (MMC)
