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In a phase 2 study, amycretin showed a mean weight reduction of up to 24.3%, which is comparable to or even greater than the weight loss seen with tirzepatide and similar to the results for retatrutide

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With drugs like Ozempic and Wegovy growing in popularity among diabetic patients, CRNAs must be aware of all potential GLP-1 and anesthesia conflicts.

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report here on a GIPR antagonist conjugated to GLP-1 analogues that reduces body weight and improves metabolic markers in preclinical and phase 1 clinical settings.