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If you add exactly 2 mL of water and the powder adds 0.1 mL of volume, your actual total volume is 2.1 mL, making the true concentration slightly lower than calculated
2017;5:e13199
Additionally, the highest doses (12.5 mg and 15 mg) tend to cause side effects more frequently than lower doses
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If your protocol is headed toward these higher doses, switching to the 1ml reconstitution when you move past 5mg simplifies the process
