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Intermittent fasting plus early time-restricted eating versus calorie restriction and standard care in adults at risk of type 2 diabetes: a randomized controlled trial

About 73% of people who discontinued treatment due to side effects did so during weeks 4 through 12, which means that making it through this window is a strong predictor of long-term success

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Key distinctions: Bloodstream: Gradual elimination over 4 to 5 weeks Body tissues: Effects decline gradually No permanent accumulation Once eliminated, tirzepatide does not remain stored indefinitely in fat or tissues

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