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Conclusions GLP-1RAs had a neutral effect on the composite cardiovascular outcomes but reduced composite kidney events in the patients with advanced DKD compared with DPP-4is.

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Yerba mate (Ilex paraguariensis), in turn, presents a more moderate caffeine profile, typically containing 0.3% to 1.8% of caffeine in dry weight4, and balanced levels of theobromine and theophylline