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Compounded tirzepatide can tolerate room temperature (up to 30 degrees Celsius / 86 degrees Fahrenheit) for limited periods, typically up to 21 cumulative days

Tirzepatide (Mounjaro and Zepbound) may cause nausea, vomiting, diarrhea, constipation, indigestion, and stomach discomfort

If the transition proves problematic with persistent issues after 4 to 6 weeks, returning to the previous peptide remains an option

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A phase 3b open-label randomized clinical trial (SURMOUNT-5) has shown that tirzepatide leads to greater weight reduction compared to semaglutide in adults with obesity or overweight conditions