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Tirzepatide works by signaling to the brain that you are full, causing you to eat less

Therefore, changing how you train, as well as when and how much you eat, may help, but you may also have to modify the medication dosage or delivery, Benjamin Gibson, PharmD, adjunct professor of pharmacy at the University of Texas at Austin tells Runners World

The dose can be increased up to 100 mg per day if needed

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While the basic contribution is often explained by LV dysfunction leading to decreased skeletal muscle perfusion and decreased O 2 utilization, this is further complicated by competing respiratory and limb skeletal muscle, and an increased catabolic state that contributes to skeletal muscle myopathy [86]