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Several important safety considerations from UK SmPCs include: Pancreatitis risk : Seek immediate medical attention for severe, persistent abdominal pain Gallbladder disease : Including cholelithiasis and cholecystitis Diabetic retinopathy complications : Particularly with semaglutide in those with pre-existing retinopathy Dehydration and acute kidney injury : Possible with severe gastrointestinal side effects Hypoglycaemia : Increased risk when used with insulin or sulfonylureas (dose adjustment of these medications may be needed) Pregnancy/breastfeeding : Weight management GLP-1 agonists (Wegovy, Saxenda) are contraindicated in pregnancy and should be avoided during breastfeeding [5] [2] Regarding mental health specifically, regulatory agencies have scrutinised GLP-1 medications for potential psychiatric adverse effects

The mean changes in waist circumference relative to baseline were 9.5 cm, 11.0 cm, and 1.5 cm, respectively

prausnitzii contribute to dysbiosis, increased gut permeability, systemic inflammation and are associated with IBD, IBS, celiac disease, Parkinsons disease, bipolar disorder, colorectal cancer and diabetes

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SSRIs are mostly used for depression and anxiety, but they are also sometimes prescribed for other disorders, including bulimia nervosa, PTSD, social anxiety, binge eating disorder, body dysmorphic disorder, and more