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On this final point, it bears note that a Phase III clinical trial recently found that 50mg oral semaglutide tablets achieved superior weight loss in adults with obesity compared with placebo

Do not use it in patients with pancreatitis, severe gastrointestinal disease, or hypersensitivity to Semaglutide base or any ingredient in the pen
The adjusted difference in mean SBP (mm Hg) change between groups was 5.9 mm Hg (95% CI 12.0 to 0.2, P = 0.059)

Actually two, but one that was serious

These were not young athletes with optimized nutrition