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[Google Scholar] 42.Connor A, Borregaard J, Buckley ST, Donsmark M, Hartoft-Nielsen ML, Maarbjerg SJ, Sndergaard FL, Vegge A, Knudsen LB, Bkdal TA

Plasma DPP-4 activity and TG excursion were reduced, and plasma active GLP-1 was increased, in sitagliptin-treated Dpp4 +/+ mice, but sitagliptin had no effect in Dpp4 / mice (Figure 1, B and C, and Supplemental Figure 3, A and B), consistent with the selectivity of sitagliptin for DPP-4 (22)

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It was therefore discontinued at a median follow up of 9.6 years following a futility analysis