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[16] [19] Some research suggests these anti-inflammatory effects may occur alongside weight loss, though the relative contributions of direct immunomodulation versus metabolic improvement remain unclear

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Given levothyroxine's narrow therapeutic index, thyroid function should be reassessed 6-8 weeks after significant weight loss or if persistent gastrointestinal symptoms develop

The medication is not suitable for patients with a personal or family history of medullary thyroid carcinoma (MTC), MEN 2 syndrome (multiple endocrine neoplasia type 2 syndrome), or pancreatitis

For many, lifestyle changes alone are insufficient, making prescription medications a crucial part of weight management

This matters for three reasons