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In enteric or vagal neurons, GLP-1 activates brain circuits that affect food intake by inducing c-Fos expression in the hypothalamus paraventricular nucleus (PVN)

Percentage of Mounjaro Users Experiencing Vision Changes The use of a GLP-1 drug is associated with a fourfold higher risk of NAION when used to treat type 2 diabetes

AMG133 is a monoclonal antibody drug designed to block the glucose-dependent insulinotropic polypeptide (GIP) receptor and simultaneously bind to two modified GLP-1 peptide segments to activate the GLP-1 receptor

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doi: 10.1503/cmaj.101281 Summary Keywords sodium-glucose cotransporter 2 inhibitors, glucagon-like peptide-1 receptor agonists, type 2 diabetes, metformin, meta-analysis Citation Deng R, Mei K, Song T, Huang J, Wu Y, Yu P, Yan Z and Liu X (2024) First-line treatment with sodium-glucose cotransporter 2 inhibitors and glucagon-like peptide-1 receptor agonists in type 2 diabetic population at low risk of cardiovascular disease: a meta-analysis