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All participants received once-weekly tirzepatide 10 mg or 15 mg for 60 weeks

Older adults are generally at higher risk of B12 deficiency due to decreased absorption capacity

Strengths of this meta-analysis include the exclusive use of randomized controlled trials and the focus on relatively homogeneous populations, improving reliability

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Tirzepatide can significantly reduce appetite and cravings, making it easier to stick with healthier eating patterns over the long term