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In the lungs, GLP-1RAs attenuate acute lung injury by maintaining alveolar-capillary barrier function, reducing neutrophil infiltration, and promoting surfactant protein expression, potentially through suppression of NLRP3 inflammasome activity

doi: 10.1056/nejmoa2302392

This is the hallmark of insulin resistance and a harbinger of diabetes

Authors contributions BG, JCL, and LAV participated in the concept and drafting of the manuscript, and performed the critical review for intellectual content

The United States is the world's dominant GLP-1 receptor agonist market by an enormous margin, with over 45% of global GLP-1 revenues generated domestically despite representing less than 5% of the world's diabetes and obesity patient population
