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GLP-1 RAs reduce gut motility by slowing gastric emptying and altering the migrating motor complex (MMC), increasing the risk of conditions like gastroparesis and bowel obstruction

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The researchers were able to measureGLP-1 in synovial fluid - the liquid within joint cavities - of patients with inflammatory rheumatic diseases. That matters becauseGLP-1-based therapies typically lead to much higher systemic exposure

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