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Research has shown that resistance training while in a calorie deficit can preserve muscle tissue and simultaneously increase strength

Studies of both mice and humans show the anti-inflammatory effects (such as reductions in TNF-) occur within hours, suggesting some actions are independent of weight loss or long-term metabolic change

They have also been associated with increases in blood sugar, which in some cases leads to a diagnosis of diabetes

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One unique finding was an imbalance in diabetic retinopathy complications in SUSTAIN-6: 3.0% of semaglutide patients vs 1.8% of placebo had retinopathy progression ( [133] )