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1 Introduction Glucagon-like peptide-1 (GLP-1) is an incretin hormone released from gut enteroendocrine cells and regulates blood sugar by increasing insulin while reducing glucagon secretion and inhibiting stomach emptying and food intake ( Ocular diseases, including glaucoma, diabetic retinopathy (DR), and age-related macular degeneration (AMD), impose a staggering global burden, with glaucoma alone affecting 95 million individuals and causing irreversible vision loss in over 10 million ( Emerging evidence positions GLP-1RAs as a transformative candidate for ocular therapeutics

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Data from LEADER, SUSTAIN-6, PIONEER 6 and REWIND allowed further investigation of the association between GLP-1RA and eGFR-related endpoints

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(This calculation could produce a different participation rate than if it was based on enrollment in all participating plans divided by enrollment in all plans eligible to participate

In more serious cases they run the risk of splitting open and causing life-threatening haemorrhages, which in the 1970s was one of the most frequent reasons for emergency surgery