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In a phase 2 randomised controlled trial published in the New England Journal of Medicine (Jastreboff et al., 2023), participants receiving the highest doses of retatrutide achieved a mean weight reduction of approximately 1724% of body weight over 48 weeks, depending on dose

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For example, a study analysing patients in the Swedish HF Registry who met the eligibility criteria for SGLT2Is drugs known for their tolerability and ease of integration into treatment found their use had tripled between 2020 and 2022