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[DOI] [PMC free article] [PubMed] [Google Scholar] 57.Poli VFS, Sanches RB, Moraes ADS, et al
In general, available pharmacopeial methods commonly used in GMP settings for peptides primarily rely on IP-RPLC, often using nonMS-compatible ion-pairing reagents, with only a few methods employing more MS-compatible alternatives
Kokrashvili Z, Mosinger B, Margolskee RF
These advances have expanded the role of GLP-1RAs from short-acting injectables to multifunctional oral formulations, creating new opportunities for targeted nanoplatforms in both metabolic and non-metabolic diseases [100, 101]
Recent data on the efficacy of tirzepatide demonstrate that incretin dual agonists have the potential to more effectively reduce HbA 1c and bodyweight than GLP-1R agonists alone [5]
Analytical Method Validation for Complex Peptide Therapeutics: HPLC and Mass Spectrometry Applications
