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usually improves over several weeks Diarrhoea or constipation : Altered bowel habits due to delayed gastric emptying Abdominal discomfort : Bloating, dyspepsia, or gastro-oesophageal reflux symptoms Practical management strategies recommended by NICE and specialist diabetes services include: Starting at the lowest licensed dose and titrating gradually according to the product's summary of product characteristics Eating smaller, more frequent meals and avoiding high-fat foods Maintaining adequate hydration, particularly if experiencing vomiting or diarrhoea Taking the injection at a consistent time as specified in the SmPC for your particular medication Less common but important adverse effects include: Injection site reactions : Rotate injection sites systematically between abdomen, thigh, and upper arm to minimise localised reactions Hypoglycaemia : Risk increases when GLP-1 agents are combined with insulin or sulphonylureas

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BLACK BOX WARNING: Tirzepatide, the active ingredient in Zepbound, is contraindicated in individuals with a history of medullary thyroid carcinoma, a family history of such, or in patients with multiple endocrine neoplasia syndrome Type 2

1hk), tesaglitazar, but not GLP-1RA/tesaglitazar, induced expression of known PPAR target genes in tissues that lack GLP-1R expression, notably the liver ( Fabp4 and Plin2 ) and skeletal muscle ( Arntl and Sema3c ) (Fig

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