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It targets both GLP-1 and GIP (glucose-dependent insulinotropic polypeptide)

The Ohio-based company reported that its pharmaceutical segment profit increased 12% to $504 million in Q4 2023, up from $451 million during the same period last year

Based on the estimated 3.8 million Part D enrollees eligible for the Medicare GLP-1 Bridge as of 2023, if 10% to 25% participate in Bridge from when the program launches in July 2026 and fill a prescription each month for the 18-month duration of the program, the cost to Medicare would be $1.3 billion to $3.3 billion (at a net monthly cost of $245 minus the $50 beneficiary copay)

This anticipatory response is mediated by vagal nerve activity and other gut hormones

doi: 10.1152/ajpregu.00517.2006

20 However, GLP-1RAs have less profound effects on reduction of hospitalisations for heart failure and renal protection than SGLT-2 inhibitors