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While the mechanism underlying the diminished insulin response to GIP in T2D has not yet been fully elucidated, receptor downregulation (55) and desensitization (56) have been suggested as potential causes

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Portillo Canales and her team conducted a retrospective study of people with obesity and type 2 diabetes using electronic health records to investigate the effects of GLP-1 drugs on testosterone over an 18-month period

Understanding these pathways is vital because the very same mechanisms that drive glycemic control and weight reduction also mediate the most common glp-1 peptides side effects

GLP-1 meds could offer a new way to help these patients