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The novel peptide is biased towards GLP-1R agonism versus GCGR with a 3-4 fold reduced potency at the GLP-1R compared to native GLP-1 and around an 8-fold reduced potency at the GCGR compared to native glucagon

[DOI] [PMC free article] [PubMed] [Google Scholar] 104.Sanyal AJ, Bedossa P, Fraessdorf M, et al

The most well-known GLP-1s have demonstrated a powerful ability to protect the heart and blood vessels

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Abbreviations GLP-1: Glucagon-like peptide-1 GLP-1RA: Glucagon-like peptide-1 receptor agonist ITT: Intention-to-treat LEADER: Liraglutide Effect and Action in Diabetes: Evaluation of Cardiovascular Outcome Results References Pernar CH, Ebot EM, Wilson KM, Mucci LA (2018) The epidemiology of prostate cancer

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