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Donovan includes a thought-provoking assessment of the effects of the GLP-1s in equality and society, calling out that, In most societies there is prejudice against people who are overweight or obese, more pronounced the case for women The more anti-obesity drugs are used recreationally rather than as a prescription written for obesity, the more likely patients will have to pay for the drugs out-of-pocket restricting recreational access to people with higher incomes Social media has raised the importance of physical appearance and for some people increased the perceived importance of appearances

GLP-1 therapies reduce inflammation across organs through rapid, weight-independent immune and metabolic effects.

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Repatha (evolocumab) is a PCSK9 inhibitor that cuts LDL by ~60% when statins aren't enough