glp-1 vagus nerve and the Degenerating Brain: Exploring Mechanistic Insights and Therapeutic Potential Mechanisms of GLP-1 in Modulating

Side Effects GI distress and other symptoms drove early drop-off

171 IR is still the key link between diabetes and PD and may impair nigrostriatal dopamine function, 172 exacerbate nigrostriatal DA depletion, 173 and enhance cognitive impairment 174 and behavioral abnormalities

Shima Hadidchi, MD Board-certified and experienced primary care physician, Dr

J Neurosci Res 72:603612

Gradual dose escalation improves gastrointestinal tolerability.78 Acute pancreatitis is a rare but documented adverse event associated with exenatide use, as reported in the FDA Adverse Event Reporting System and observational studies.79 Current guidelines from the American Association of Clinical Endocrinologists recommend cautious use of GLP-1RAs in T2DM patients with a history of pancreatitis80 (See Figures 2 and 3)

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