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As the accessibility of these medications continues to rise and patient uptake increases, its crucial that we understand the neural mechanisms underlying the effects were seeing, said Lorenzo Leggio, MD, PhD, clinical director of NIHs National Institute on Drug Abuse

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At the same time, semaglutide increased the VTA dopamine neuron activity during sucrose collection, independent of task performance as mice without drug-induced reduction in reward-seeking showed increased neuronal activity during reward consumption

The development of dual GIPRGLP1R coagonists that bind to either one or the other receptor (sequence-mixed dual agonists) has emerged as an innovative therapeutic strategy for obesity and type 2 diabetes

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