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In findings from a randomized controlled trial, youths with severe obesity who achieved a 5% or greater BMI reduction during the trials run-in phase and were randomly assigned to exenatide extended-release (Bydureon, AstraZeneca) had a smaller BMI increase after weight loss than those randomly assigned to placebo

A 2020 study in the European Journal of Pharmacology found that tolerance does develop toward GLP-1 receptor agonist glucose-lowering effects in mice

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Coverage typically applies to members with type 2 diabetes or documented cardiovascular diseasenot primarily for weight loss in otherwise healthy individuals

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