is metformin a glp 1 vs. GLP-1 Receptor Agonists: Which Diabetes Medication Right for You? Metformin vs GLP-1: Key Differences
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doi: 10.1021/acs.jmedchem.5b00726 61 Eli Lilly and Company

The cornerstone of safe GLP-1 therapy is open communication with your healthcare team

For weight loss, the data puts retatrutide ahead: 24.2 percent at 12 mg over 48 weeks versus 14.9 percent for semaglutide at 2.4 mg over 68 weeks

Am J Physiol 275: G984-992, 1998

Br Med J
With semaglutide, most patients notice appetite suppression within the first few weeks, with measurable weight loss beginning by weeks 4 to 8