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Clinical trials and studies have shown that skin-related side effects, although not very common, can occur in some individuals using semaglutide

Injection site management Early dosing does not directly affect injection site reactions, but it is worth noting that rotating injection sites remains important regardless of timing

Epidemiological studies have shown that metabolically healthy, normal-weight individuals exhibit higher urinary KB levels compared to metabolically unhealthy, obese populations [9]

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infusion of hypertonic saline (5% NaCl) [755]

Generally, despite this reaction, which typically resolves within 4-8 weeks, patients remain asymptomatic, and do not discontinue the drug [110]