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6 Safety and tolerability 6.1 Adverse events reported in clinical trials Tirzepatide offers therapeutic benefits and demonstrates a safety profile comparable to that of other incretin-based therapies, such as semaglutide and dulaglutide (Jung and Jung 2022)

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A report from the Institute for Safe Medication Practices (ISMP) documented multiple adverse events associated with compounded semaglutide, including hypoglycemia and severe nausea attributed to concentration errors [12]

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