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If you are considering microdosing, discuss your reasons with a licensed clinician and ask about alternative solutions

According to PubMed, recent comprehensive reviews document effects on cardiovascular protection (reduced major adverse cardiovascular events), neuroprotection (reduced neuroinflammation, potential effects on Alzheimer's pathology), renal protection (reduced albuminuria and renal decline), hepatic improvement (reduced steatosis and fibrosis markers), adipose tissue remodeling (enhanced mitochondrial biogenesis, beige adipocyte programming, reduced visceral fat inflammation), modulation of gut microbiota composition, and even preliminary signals in obstructive sleep apnoea, substance use disorders, and tumour biology (Lu et al., 2024, DOI

The BNF advises that patients who regularly consume alcohol should discuss appropriate paracetamol use with their GP, as lower maximum doses may be recommended in chronic alcohol misuse

[DOI] [PMC free article] [PubMed] [Google Scholar] Sirohi S., Schurdak J.D., Seeley R.J., Benoit S.C., Davis J.F
This includes all caffeinated drinks, not just coffee
