glp 1 drugs metformin What next after metformin? A GPnotebook Shortcut Medication Options for Type 2

Approximately 70% of an oral dose is absorbed in the small intestine, minimally metabolised, and excreted unchanged in urine within 24 hours

Gastrointestinal effects GI side effects dominate the adverse event profile, consistent with all GLP-1 receptor agonists

The GLP-1 hormone is rapidly inactivated by the enzyme DPP-4, with a half-life of only 12 min

Release and Function of GLP-1 GLP-1 is a hormone, or chemical messenger, that gets released during digestion

GLP-1RAs exert glycemic control through multiple mechanisms, including the stimulation of insulin secretion under hyperglycemic conditions, suppression of glucagon secretion during hyperglycemia, deceleration of gastric emptying to mitigate postprandial glucose spikes, reduction of caloric intake, and promotion of weight loss.71,8183 Short-acting GLP-1RAs, such as exenatide and lixisenatide, primarily reduce nocturnal and fasting glucose levels, while maintaining their effect on gastric emptying over prolonged treatment periods

Alternatively, they may suggest other treatments