glp 1 gpcr Glucagon-like peptide-1 receptor Frontiers | G protein-coupled receptors

It can affect patients both on a psychological and physical level, with overweight and obese people found to be at risk for diabetes, cardiovascular disease, cancer, and premature death [2]

Diabetes Metab Syndr Obes Targets Ther

Weight Management Benefits One of the most well-known effects of GLP-1 medications is weight loss

A February 2026 peer-reviewed study (Kasher Meron et al.) found an 11% higher fragility fracture risk in GLP-1 users aged 65+ with Type 2 diabetes versus those on other diabetes medications - a retrospective study showing association, not proven causation

Glucagon-like peptide-1 (GLP-1) medications such as Wegovy have transformed weight loss treatment, but like all medications, they come with potential side effects that affect individual patients differently

Effective weight loss at a fraction of the cost