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[6] Eli Lilly and Company, 'Lilly's triple agonist, retatrutide, delivered weight loss of up to an average of 71.2 lbs along with substantial relief from osteoarthritis pain in first successful Phase 3 trial', Investor press release, Dec

This scenario leads to an increase in oxidative stress (OS), which is related to mitochondrial dysfunction, accumulations of protein and oxidated lipids, and an impairment of the antioxidant system [64,65,66,67,68,69,70]

The medication commonly causes gastrointestinal side effects, particularly nausea, vomiting, and diarrhoea, especially during the initial titration period

Fasting can potentially improve metabolic health and complement GLP-1 medications, but the effect varies by individual

Statistics were calculated in GraphPad Prism (9.4.1) using a one-way ANOVA with a Sidaks multiple comparison test (DMSO vs
