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45 Products that are a combination of a DPP-4 inhibitor and an SGLT2 inhibitor (sitagliptin/ertugliflozin, saxagliptin/dapagliflozin, and linagliptin/empagliflozin) may be used to further lower A1C and provide increased CV benefit in patients who are not meeting A1C goals on dual therapy

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Phase III EVOKE (NCT04777396) and EVOKE+ (NCT04777409) trials are evaluating the effects of oral semaglutide on AD biomarkers and neuroinflammation in early symptomatic AD [29] (Fig

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