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We recommend fasting for high-carbohydrate content clear liquids (10% glucose) for 8 h before procedures requiring anaesthesia for patients taking GLP-1 RAs without significant gastrointestinal symptoms (significant symptoms include severe nausea, vomiting, and inability to tolerate oral intake and do not include fullness or early satiety) (C)

In animal studies , GLP-1 drugs lowered dopamine signaling, which reduced interest in rewarding behaviors

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Antifibrotic drugs Selonsertib (GS-4997) is a selective inhibitor of apoptosis signal-regulating kinase 1 (ASK1)