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Two genetic variants linked to the effects of GLP-1 drugs for obesity GLP-1 medicines for the treatment of obesity show considerable variability between individuals

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(2026) Sci Adv 12 : eadw0899-eadw0899 PubMed: 41637494 Search on PubMed DOI: Primary Citation Related Structures: 9E2A PubMed Abstract: Glucagon-like peptide-1 receptor agonists (GLP-1RAs) are effective therapies for type 2 diabetes (T2D) and obesity, yet patient responses are variable, with GLP1R gene variation potentially linked to therapeutic outcomes