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doi: 10.3389/fendo.2024.1368079
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Abstract Objective: A novel dual GIP and GLP-1 receptor agonist, LY3298176, was developed to determine whether the metabolic action of GIP adds to the established clinical benefits of selective GLP-1 receptor agonists in type 2 diabetes mellitus (T2DM)
The receptor selectivity difference matters clinically because GIP activation independently promotes satiety, reduces appetite-driven eating, and may enhance energy expenditure through brown adipose tissue activation
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Health plans may also institute duration or quantity limits, capping the length of time that a drug will be reimbursed
