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Retatrutide is an investigational triple receptor agonist targeting GLP-1, GIP, and glucagon receptors to promote weight loss and improve blood sugar control in obesity and type 2 diabetes

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It will complete a phase III clinical trial in 2021 to manage type 2 diabetes mellitus (T2DM) (Urva et al

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Lately, attention has been directed to GIP and its role in glucose homeostasis, and efforts are underway to develop compounds that mimic GIP actions in addition to those of GLP-1

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In the Technical Note that supported the publication of Order #97/2025, ANVISA stated that the routine compounding of semaglutide and tirzepatide is unfeasible from a sanitary perspective

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Collectively, these studies paved the way for clinical investigation into the feasibility of using pharmacological inhibition of DPP-4 to improve glycaemic control in patients with T2DM

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