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Retatrutide is an investigational triple receptor agonist targeting GLP-1, GIP, and glucagon receptors to promote weight loss and improve blood sugar control in obesity and type 2 diabetes

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It will complete a phase III clinical trial in 2021 to manage type 2 diabetes mellitus (T2DM) (Urva et al

Lately, attention has been directed to GIP and its role in glucose homeostasis, and efforts are underway to develop compounds that mimic GIP actions in addition to those of GLP-1

In the Technical Note that supported the publication of Order #97/2025, ANVISA stated that the routine compounding of semaglutide and tirzepatide is unfeasible from a sanitary perspective

Collectively, these studies paved the way for clinical investigation into the feasibility of using pharmacological inhibition of DPP-4 to improve glycaemic control in patients with T2DM
