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Patients should use the lowest effective dose for the shortest duration necessary to manage their symptoms

SPINK1 p.N34S variant weakens trypsin inhibition, conferring an approximately 2.8-fold increased risk of elevated pancreatic enzymes and gastrointestinal symptoms during GLP-1RA therapy [60,61]

Pregnant individuals, those with renal impairment, or patients in early GLP-1 dosing phases (first 4-8 weeks) should avoid fasting without explicit medical clearance

The daily dosing of both Tresiba and liraglutide probably contributes to the confusion

Figure was created by the author