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What makes metformin particularly well-suited to first-line use is its side effect profile

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Telogen effluvium does occur, and there are also associations with increased testosterone levels in the blood

Second, success will depend on aligning with the new demand drivers emerging from GLP-1 usage

Obesity (Exp(B) = 1.63, p = .02) and having diabetes (HbA1c 48mmol/L), rather than gestational diabetes were also associated with a significantly higher emLSCS rates (Exp(B) = 4.690, p = .01)

This means retatrutide may offer additional benefits and improve outcomes , although more evidence is needed as clinical trials continue
