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A study published in August 2025 found that lean muscle mass loss via a mouse model was less than previous studies had reported, and also found that a good portion of the And research presented at the European Congress on Obesity (ECO 2025) reported that adults taking GLP-1 drugs were able to retain muscle while losing weight by strength training and eating enough protein

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2025;101(4):762-771.e13

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Fatigue is another commonly reported experience, particularly during the first weeks of treatment or after dose increases

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While some findings have generated interest, research remains ongoing

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