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Role of High Blood Sugar (Hyperglycemia) In Diabetes Mellitus, long-term high glucose levels lead to:- Glycation of collagen Excess glucose binds to proteins forms AGEs (Advanced Glycation End Products) These AGEs accumulate in shoulder joint tissues (capsule, ligaments)

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Patients with type 2 diabetes already have a two- to threefold higher baseline risk of pancreatitis due to metabolic stress, dyslipidemia, and insulin resistance

11 It is often administered as a weekly subcutaneous injection, but it can also be taken daily orally, as previously noted in Table 1

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That appetite reduction is a big reason GLP-1 agonists lead to weight loss