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A review by Frank Duca and graduate students Hallie Wachsmuth and Savanna Weninger at the University of Arizona, Tucson, USA, reveals a more complicated picture, with many different interacting neural and hormonal signals, with increasing evidence for the vital role played by the microbes in the gastrointestinal tract

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As a result, dozens of upstream and downstream neural targets of 5-HT have been identified, revealing a multitude of neural circuits involved in mediating the anorexigenic effect of 5-HT

To accommodate GLP-2 rather than GLP-1, GLP-2R fine-tunes the conformations of the extracellular parts of transmembrane helices (TMs) 1, 5, 7 and extracellular loop 1 (ECL1)

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