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GLP-1 also modulates local inflammation through specialized cell populations

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Certain GLP-1 drug labels have been updated to include postmarketing reports of ileus, reflecting concerns raised through adverse event reporting and ongoing safety monitoring

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These data are in agreement with non-controlled clinical studies reporting that 72 h of native GLP-1 infusion improved regional and global left ventricular performance in patients with acute myocardial infarction and severe systolic dysfunction [619]

The analysis suggests that gut microbial communities and metabolites may contribute to variability in patient responses to these treatments